Clinical Research & Resources

Since 2003 our partners at Good Clean Love have worked with leading scientists and doctors to develop products that support sexual health and feminine hygiene – with low osmolality and mimicking a healthy vaginal pH – without harmful petrochemicals, parabens and synthetic fragrances. These scientifically-advanced products are being recommended by thousands of medical providers nationwide, for patients of all ages and at all stages of life, to improve their vaginal health and enhance their intimate relationships.

UN Global Consultation On Personal Lubricants

Non-toxic Lubricants For Vaginal And Rectal Intercourse: Anatomy And Physiology

Reviews evidence of epithelial damage and resulting instances of BV resulting from the use of higher osmolality personal lubricants during intercourse. (2016)

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Johns Hopkins University

Studies Raise Questions About Safety Of Personal Lubricants

Reports that isosmolar lubricants, such as agar-based Good Clean Love, did not damage cervical tissue samples or boost sexually transmitted infection rates. (2012)

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Backed By Clinical Studies: Promoting Conditions That Match Optimal Vaginal pH

Patented Bio Match™ products are formulated to provide women with healthier options for combating a variety of conditions and symptoms. Restore Moisturizing Vaginal Gel and BiopHresh Vaginal Probiotic Supplement support the growth of good lactobacilli. BioNude Ultra Sensitive Personal Lubricant is iso-osmotic; a characteristic shown to reduce epithelial damage during intercourse. Balance Moisturizing Personal Wash and Rebalance Feminine Wipes clean and are balanced to optimal pH levels. Try them in your clinic. Provide samples to your patients. They’ll thank you!

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Is Wetter Better? An Evaluation of Over-the-Counter Personal Lubricants for Safety and Anti-HIV-1 Activity
Charlene S. Dezzutti, Elizabeth R. Brown, Bernard Moncla, et al. International DOI Foundation (2012)


Because lubricants may decrease trauma during coitus, it is hypothesized that they could aid in the prevention of HIV acquisition. Therefore, safety and anti-HIV-1 activity of over-the-counter (OTC) aqueous- (n = 10), lipid- (n = 2), and silicone-based (n = 2) products were tested. None of the lubricants that had a moderate to high therapeutic index protected the mucosal tissue. These results show hyperosmolar lubricant gels were associated with cellular toxicity and epithelial damage while showing no anti-viral activity. The two iso-osmolar lubricants, Good Clean Love and PRÉ, and both silicone-based lubricants, Female Condom 2 lubricant and Wet Platinum, were the safest in our testing algorithm.

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Characterization of Commercially Available Vaginal Lubricants: A Safety Perspective
Ana Raquel Cunha, Rita M. Machado, Ana Palmeira-de-Oliveira, et al. (2012)


Twelve commercially available gel products were tested for pH value, pH buffering capacity, osmolality and cytotoxicity relevant to vaginal delivery. Obtained data were analyzed in light of the recent Advisory Note by the World Health Organization (WHO) for personal lubricants to be concomitantly used with condoms. Results showed that most products do not comply with pH and osmolality recommended standards, thus posing a potential hazard. Four products presented values of osmolality around three-times higher than the maximum acceptable limit of 1200 mOsm/kg. In vitro cell testing further identified substantial cytotoxicity even at 1:100 dilutions for three products, contrasting with no significant effect of up to at least a 1:5 dilution of a Universal Placebo gel. However, no direct correlation between these last results and pH or osmolality was found, thus suggesting that the individual toxicity of specific formulation components plays an important role in the outcome of a particular product.

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Women's Perceptions About Lubricant Use and Vaginal Wetness During Sexual Activities
Kristen N. Jozkowski PhD, Debby Herbenick PhD, MPH, Vanessa Schick PhD, et al. International Society For Sexual Medicine (2012)


Exogenous lubricant use in the United States is common among women; however, there is little empirical research describing women's perceptions of lubricants, lubricant use, and vaginal wetness or dryness during penile‐vaginal intercourse or other sexual behaviors. Findings suggest that women generally feel positively about lubricants and lubricant use and prefer vaginal‐penile intercourse to feel more wet. Such insights into women's perceptions of lubricants and lubricant use can be helpful to medical and other health professionals as well as sexual health educators, who routinely make recommendations to women about ways to incorporate products, such as lubricants, into their sexual activities.

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Effects of Feminine Hygiene Products on the Vaginal Mucosal Biome
Bisiayo Fashemi, Mary L. Delaney M.A., Andrew B. Onderdonk Ph.D. & Raina N. Fichorova M.D., Ph.D. Microbial Ecology in Health and Disease (2013)


This study evaluates in-vitro their effects on Lactobacillus crispatus, which is dominant in the normal vaginal microbiota and helps maintain a healthy mucosal barrier essential for normal reproductive function and prevention of sexually transmitted infections and gynecologic cancer. Some OTC vaginal products may be harmful to L. crispatus and alter the vaginal immune environment. Illustrated through these results, L. crispatus is essential in the preservation of the function of vaginal epithelial cells in the presence of some feminine hygiene products.

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Hyperosmolar Sexual Lubricant Causes Epithelial Damage in the Distal Colon: Potential Implication for HIV Transmission
Edward J. Fuchs, Linda A. Lee, Michael S. Torbenson, et al. The Journal of Infectious Diseases (2007)


Many sexual lubricants are hyperosmolar. Hyperosmolar enemas induce epithelial damage, and enema use has been associated with an increased risk of HIV infection. To inform the development of rectal microbicide formulation, we evaluated the effects of hyperosmolar gels on the rectal mucosa. Rectally applied hyperosmolar gels induce greater epithelial denudation and luminal secretion than iso-osmolar gels. Because denudation plausibly increases the risk of HIV transmission, hyperosmolar gels make poor rectal microbicide formulations, and hyperosmolar sexual lubricants may increase susceptibility to HIV infection.

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